Effects of X-monosomy and X-linked imprinting on superior temporal gyrus morphology in Turner syndrome
نویسندگان
چکیده
منابع مشابه
Genomic imprinting effects of the X chromosome on brain morphology.
There is increasing evidence that genomic imprinting, a process by which certain genes are expressed in a parent-of-origin-specific manner, can influence neurogenetic and psychiatric manifestations. While some data suggest possible imprinting effects of the X chromosome on physical and cognitive characteristics in humans, there is no compelling evidence that X-linked imprinting affects brain mo...
متن کاملEnlarged temporal lobes in Turner syndrome: an X-chromosome effect?
Gender differences in brain morphology have previously been reported in the temporal lobe and an 'X-chromosome dosage effect' has been described in Turner syndrome (45,X). To examine this further, we investigated temporal lobe morphology, metabolism and function in nine children with non-mosaic Turner syndrome using magnetic resonance imaging, (1)H magnetic resonance spectroscopy and neuropsych...
متن کاملThe evolution of X-linked genomic imprinting.
We develop a quantitative genetic model to investigate the evolution of X-imprinting. The model compares two forces that select for X-imprinting: genomic conflict caused by polygamy and sex-specific selection. Genomic conflict can only explain small reductions in maternal X gene expression and cannot explain silencing of the maternal X. In contrast, sex-specific selection can cause extreme diff...
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OBJECTIVE To evaluate volumes and asymmetry of superior temporal gyrus (STG) and correlate these measures with a neurocognitive evaluation of verbal performance in Williams syndrome (WS) and in a typically developing age-matched and sex-matched group. BACKGROUND Despite initial claims of language strength in WS, recent studies suggest delayed language milestones. The STG is implicated in ling...
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X-linked Alport syndrome (AS) is a heritable disorder which is associated with mutations in the type IV collagen oc5(IV) chain gene (COL4A5) located on chromosome X. Following renal transplantation, an average of 6% of male AS patients develop anti-GBM nephritis. We studied the specificity of the antibodies against type IV collagen in the serum of a patient with COL4A5 partial deletion. The spe...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2003
ISSN: 0006-3223
DOI: 10.1016/s0006-3223(03)00289-0